Educational Articles | Medical Conditions

Alzheimer’s

• The Potential Therapeutic Effects of THC on Alzheimer's Disease

https://www.ncbi.nlm.nih.gov/pubmed/25024327

• Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study

https://www.ncbi.nlm.nih.gov/pubmed/26757043

• Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer’s Disease

https://www.frontiersin.org/articles/10.3389/fphar.2020.01097/full

Autism

• Real Life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy

https://www.nature.com/articles/s41598-018-37570-y

Cancer

• Breast Cancer

A study of breast cancer patients' use of cannabis before, during and after treatment

https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.33906

• Cannabis and Cancer

https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html

• A user’s guide to cannabinoid therapies in oncology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176373/

• Cannabinoids as therapeutic agents in cancer: current status and future implications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171598/

• Cannabis for the Management of Cancer Symptoms: THC Version 2.0?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961457/

• Integrating Cannabis Into Clinical Cancer Care For Apetite Stimulation, Nausea, Pain and Peripheral Neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791148/

• Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964193/

• World’s First Trial to Treat Glioblastoma with Medical Cannabis

(A)  https://www.bioceuticals.com.au/education/article/the-first-patient-to-complete-our-ground-breaking-medicinal-cannabis-trial

(B)  https://www.fxmedicine.com.au/content/medicinal-cannabis-brain-cancer-dr-janet-schloss

• Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida

https://www.liebertpub.com/doi/full/10.1089/jpm.2018.0528

• CBD Enriched Cannabis Was More Effective at Killing Leukemia and Paediatric Brainstem Glioma Cancer Cells than THC Varieties

https://www.newcastle.edu.au/newsroom/featured/tests-show-potential-for-medicinal-cannabis-to-kill-cancer-cells

• Medical Cannabis use in Head and Neck Squamous Cell Carcinoma patients treated with radiotherapy

https://link.springer.com/article/10.1007%2Fs00520-016-3180-8

Ovarian Cancer

• Enhancing ovarian cancer conventional chemotherapy through the combination with cannabidiol loaded microparticles

https://www.sciencedirect.com/science/article/abs/pii/S0939641120302113?via%3Dihub

Pancreatic Cancer

• Anticancer Effect of New Cannabinoids Derived from Tetrahydrocannabinolic Acid on PANC-1 and AsPC-1 Human Pancreas Tumor Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337241/#!po=2.08333

• Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663976/

Cannabinoid Hyperemesis Syndrome

• Cannabinoid hyperemesis syndrome (CHS) is a condition that leads to repeated and severe bouts of vomiting. How rare or common is it?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576702/

https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cannabinoid-hyperemesis-syndrome.html

Cannabis: A Better Alternative to Benzodiazepines?

• Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis

https://www.liebertpub.com/doi/10.1089/can.2018.0020

The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD

https://www.liebertpub.com/doi/full/10.1089/can.2015.29003.ebr

CBD 

• A Single Dose Of Cannabidiol Reduces Blood Pressure In Healthy Volunteers In A Randomized Crossover Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/

• CBD: What You Need to Know Before You Try

https://www.cedars-sinai.org/blog/cbd-safe.html

• CBD Oil And Cancer: 9 things to know

https://www.mdanderson.org/publications/cancerwise/cbd-oil-and-cancer--9-things-to-know.h00-159306201.html

• Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure

https://www.ncbi.nlm.nih.gov/pubmed/30550613

• Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol

https://pediatrics.aappublications.org/content/early/2020/05/21/peds.2019-3256

• Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research

https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-020-00251-0

• Cannabidiol for the Treatment of Cannabis Use  Disorder: a phase 2a, double-blind, placebo-controlled, randomised,  adaptive Bayesian trial           

https://pubmed.ncbi.nlm.nih.gov/32735782/

• Cannabidiol Improves Blood Flow to Brain’s Hippocampus

https://neurosciencenews.com/cbd-hippocampus-16806/

• Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase 1 Clinical Trial

https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.2071

• Cannabidiol Reduces Binge Eating Behavior in Mice

https://helda.helsinki.fi/handle/10138/332343

Colitis

• THC, not CBD, protected against colitis through activation of CB2 receptors and through enterocytes in a mouse model

https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjaa253/6040793?redirectedFrom=fulltext

Consumption Methods

• Explore a variety of options for consuming cannabis: from edibles to topicals and inhalation, this will help guide you to administering cannabis medicine based on your needs and comfort level.

https://www.medicaljane.com/category/cannabis-classroom/consuming-cannabis/#smoking-cannabis

Depression

• The Effectiveness of Cannabis Flower for Immediate Relief from Symptoms of Depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309674/

Dosing

• Practical considerations in medical cannabis administration and dosing

https://www.sciencedirect.com/science/article/abs/pii/S0953620518300049

Drug Interactions

• Medicinal Cannabis—Potential Drug Interactions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473892/

• Probable Interaction Between Warfarin and Inhaled and Oral Administration of Cannabis

https://europepmc.org/abstract/MED/31319733

• Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions

https://www.karger.com/Article/FullText/507998

• With Commercial Cannabis-Based Products Increasingly Being Used in the Community...There Is An Increased Potential For A Drug–Drug Interaction (DDI) Between Cannabis-Based Products and Conventional Treatments

https://www.liebertpub.com/doi/10.1089/can.2020.0053

Effects of Cannabis Smoking on the Lung                                    

https://www.atsjournals.org/doi/full/10.1513/AnnalsATS.201212-127FR

Elder Use

• Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly

https://www.ncbi.nlm.nih.gov/pubmed/29398248

• Medical Cannabis in the Skilled Nursing Facility: A Novel Approach to Improving Symptom Management and Quality of Life

https://www.sciencedirect.com/science/article/pii/S1525861018306625

Endometriosis

• Self-management strategies amongst Australian women with endometriosis: a national online survey

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-019-2431-x

Epilepsy

• Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767492/

Fibromyalgia

• Medical Cannabis for the Treatment of Fibromyalgia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176373/

• Safety and Efficacy of Medical Cannabis in Fibromyalgia

https://www.ncbi.nlm.nih.gov/pubmed/31195754

• Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia:an observational cross-over single centre study

https://pdfs.semanticscholar.org/8fb2/0c23fcd56d9140714e95ef5f9f37ebfc451d.pdf

Human Reproduction

• Cannabis smoking linked with higher sperm concentrations

https://www.hsph.harvard.edu/news/press-releases/marijuana-smoking-sperm-counts/

Inflammatory Bowel Diseases

• Chron's and Colitis Foundation 

https://www.crohnscolitisfoundation.org/sites/default/files/legacy/resources/MedicalCannabis-PositionStatement-November2018.pdf

• Use of Medical Cannabis in Patients With Inflammatory Bowel Disease

https://www.gastroenterologyandhepatology.net/archives/october-2018/use-of-medical-cannabis-in-patients-with-inflammatory-bowel-disease/

Migraines

• Emerging Role of (Endo)Cannabinoids in Migraine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928495/

• Cannabis reduces headache and migraine pain by nearly half

https://www.sciencedaily.com/releases/2019/11/191125100353.htm

https://www.ncbi.nlm.nih.gov/pubmed/31715263

Multiple Sclerosis

• Cannabidiol to Improve Mobility in People with Multiple Sclerosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874292/

• Cannabis for Multiple Sclerosis: Prescriber’s Perspective 

https://www.neurologyadvisor.com/advisor-channels/multiple-sclerosis-advisor/cannabis-for-multiple-sclerosis-prescribers-perspective/

• MS and Use of Medical Cannabis: A Retrospective Review Evaluating Symptom Outcomes

https://n.neurology.org/content/92/15_Supplement/P5.2-106

Osteoarthritis

• Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids

https://www.ncbi.nlm.nih.gov/pubmed/29635215

Pain

• The Endocannabinoid System, Cannabinoids, and Pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/

• Personal experience and attitudes of pain medicine specialists in Israel regarding the medical use of cannabis for chronic pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074811/

• A Cost-Effectiveness Model for Adjunctive Smoked Cannabis in the Treatment of Chronic Neuropathic Pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446169/

• Medical Cannabis for Neuropathic Pain

https://www.ncbi.nlm.nih.gov/pubmed/29388063

• The Impact of Medical Cannabis on Intermittent  and Chronic Opioid Users with Back Pain: How Cannabis Diminished  Prescription Opioid Usage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480723/

Parkinson’s

• Marijuana for Parkinson’s Disease?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450681/

Pediatric Use

• Cannabis Medicine in Pediatric Healthcare

https://www.childrenscolorado.org/health-professionals/professional-resources/charting-pediatrics-podcast/medical-marijuana-in-children/

• Cannabinoids in Pediatrics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473390/

Post-Traumatic Stress Disorder

• Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.

https://www.ncbi.nlm.nih.gov/pubmed/30543451

• A review of medical marijuana for the treatment of post-traumatic stress disorder: Real symptom re-leaf or just high hopes?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007739/

Psychiatric Concerns

• Cannabis-Induced Bipolar Disorder with Psychotic Features

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811144/

• Cannabis-Induced Psychosis: A Review 

https://www.psychiatrictimes.com/substance-use-disorder/cannabis-induced-psychosis-review/page/0/4

Replacing Opioids With Cannabis

• Daily Cannabis Use Lowers Odds of Using Illicit Opioids Among People Who Have Chronic Pain

https://news.ubc.ca/2019/11/19/daily-cannabis-use-lowers-odds-of-using-illicit-opioids-among-people-who-have-chronic-pain/

Sickle Cell Disease

• Study: Medical marijuana may reduce hospitalizations among patients with sickle cell disease

https://www.nhlbi.nih.gov/news/2020/study-medical-marijuana-may-reduce-hospitalizations-among-patients-sickle-cell-disease

Spinal Cord Injury

• Utilization of Medicinal Cannabis for Pain by Individuals with Spinal Cord Injury

https://www.nature.com/articles/s41394-019-0208-6

Terpenes/Terpenoids And Their Importance 

• The healing power of cannabis most likely resides in terpenes/terpenoids and phytocannabinoids, of which particular  compounds, their quantity and ratio to  each other play the most important role in the treatment of particular diseases. It should be emphasized that flavonoids, flavonoid glycosides, polyphenol and other biodynamic compounds also contribute.

https://www.karger.com/Article/Pdf/509733

Viewpoints

• Harvard Medical School: Medical Cannabis

https://www.health.harvard.edu/blog/medical-marijuana-2018011513085

• Mayo Clinic Q & A: Treatment With Medical Cannabis

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-treatment-with-medical-cannabis/

• Perspectives on Cannabis Research—Barriers and Recommendations

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2767410?guestAccessKey=273b25f3-1d70-4e84-8598-34f152fb6f8f&utm_source=twitter&utm_medium=social_jamapsyc&utm_term=3428888859&utm_campaign=article_alert&linkId=91080365

• Why Doctors Know Almost Nothing About The Health Effects Of Cannabis

https://www.aamc.org/news-insights/why-doctors-know-almost-nothing-about-health-effects-marijuana

• You’re Missing The Full Story On Medical Cannabis - Joseph (Yossi) Tam, DMD, PhD, Director of the Multidisciplinary Center for Cannabinoid Research at Hebrew University of Jerusalem

https://blogs.timesofisrael.com/youre-missing-the-full-story-on-medical-cannabis/

Withdrawl

• If Cannabis Becomes A Problem: How To Manage Withdrawal

https://www.health.harvard.edu/blog/if-cannabis-becomes-a-problem-how-to-manage-withdrawal-2020052619922?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork

• More Than Half of People Using Cannabis for Pain Experience Multiple Withdrawal Symptoms

https://medicine.umich.edu/dept/psychiatry/news/archive/202101/more-half-people-using-cannabis-pain-experience-multiple-withdrawal-symptoms